DAP12 interacts with RER1 and is retained in the secretory pathway before assembly with TREM2 - Cellular and Molecular Life Sciences

DNAX-activating protein of 12 kDa (DAP12) is a transmembrane adapter protein expressed in lymphoid and myeloid lineage cells. It interacts with several immunoreceptors forming functional complexes that trigger intracellular signaling pathways. One of the DAP12 associated receptors is the triggering…