Analgesic impact of intra-operative opioids vs. opioid-free anaesthesia: a systematic review and meta-analysis - PubMed

Opioids are administered peri-operatively for postoperative analgesia, and intra-operatively to control the sympathetic response to surgical stimuli, frequently as a surrogate for presumed pain. However, opioid use during surgery is a matter of dispute in contemporary practice and carries the risk o…